The SportsLine Projection Model simulates every FBS college football game 10,000 times. Before locking in any Week 4 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine's proven model.
ET, CBS) and Notre Dame is a 3.5-point underdog against Ohio State (7:30 p.m. Elsewhere in college football, Alabama is a 7-point favorite at home against Ole Miss (3:30 p.m. The latest Week 4 college football odds from the SportsLine consensus list Oregon as 21-point favorites at home in that 330 p.m. However, Colorado has struggled mightily against Oregon over the years, losing nine of their last 10 games against the Ducks. Meanwhile, the Buffaloes remained undefeated after a thrilling comeback victory over rival Colorado State. Nix has already thrown eight touchdown passes this season, helping the Ducks average 58 points per game. One of the marquee matchups on the Week 4 college football schedule features Bo Nix and the Oregon Ducks hosting Shedeur Sanders and the Colorado Buffaloes.
